Publications

Peer reviewed Publications

2026

85. Divergent Reactivity of Diketopyrrolopyrroles: Ring-Opening with Amines

Almodovar, V. A. S.; Oliveira, G. F.; Candeias, N. R.; Paz, F. A. A.; Tomé, A. C.

Org. Lett., 2026, accepted. (DOI: 10.1021/acs.orglett.5c04654)

84. Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

Vogel, I. C.; Verganista, M. J.; Candeias, N. R.

ChemMedChem, 2026, accepted. (DOI: 10.1002/cmdc.202500976)

2025

83. Glioblastoma Antitumoral Activity of Tetrahydroquinoline-derived Triarylmethanes

Branco, D. S. N.; Yektaei, Z. H.; Chandrabose, S.; Paz, F. A. A.; Kandhavelu, M.; Candeias, N. R.

RSC Med. Chem., 2025, 16, 6204. (DOI: 10.1039/D5MD00585J)

82. Synthesis of meta-Amination of Pyridines via Multicomponent Cascade Reaction

Francisco, T. N.; Candeias, N. R.; Guieu, S.; Sousa J. L. C.; Gomes, R. F. A.; Afonso, C. A. M.; Silva, A. M. S.; Albuquerque, H. M. T.

Org. Lett., 2025, 27, 11757. (DOI: 10.1021/acs.orglett.5c03509)

81. Halogen Bonding as a Tol to Control Morphology and Charge Transport in Organic Semiconductors

Ruoko, T-P.; Stoeckel, M-A.; Puttreddy, R.; Yang, C-Y.; Zhang, S.; Wu, Z.; Candeias, N. R.; Samorí, P.; Woo, H. Y.; Fabiano, S.; Priimagi, A.

Angew. Chem. Int. Ed., 2025, 64, e202424979. (DOI: 10.1002/anie.202424979)

80. Protecting Group-free Photocatalyzed O-Arylation of Quinic Acid

Bárbara, M. A.; Candeias, N. R.; Veiros, L. F.; Menezes, F.; Gualandi, A.; Cozzi, P.; Afonso, C. A. M.;

Tetrahedron Green Chem., 2025, 5, 100070. (DOI: 10.1016/j.tgchem.2025.100070)

2024

79. Recent Advances in Chlorination: Novel Reagents and Methods from the Last Decade

Vogel, I. C.; Pinto, D. C. G. A.; Candeias, N. R.

SynOpen, 2024, 8, 360. (DOI: 10.1055/a-2446-9165)

78. Light-Driven Site-Selective Glycosylation of Native Carbohydrates

Pacheco, J. A.; Candeias, N. R.

Angew. Chem. Int. Ed., 2024, 63, e202414424. (DOI: 10.1002/anie.202414424)

77. Novel tetrahydroquinoline derivatives induce ROS-mediated apoptosis in glioblastoma cells

Koochakkhani, S.; Branco, D. S. N.; Alonso, A. V.; Murugesan, A.; Sarkar, P.; Caires, C. J. N.; Devanesan, S.; AlSalhi, M. S.; Candeias, N. R.; Kandhavelu, M.

Eur. J. Pharm. Sci. , 2024, 200, 106842. (DOI: 10.1016/j.ejps.2024.106842)

76. Halimane Derivatives from Plectranthus ornatus Codd. as Novel Anti-cancer Agents

Bangay, G.; Brauning, F. Z.; Kowalczyk, T.; Merecz-Sadowska, A.; Synowiec, E.; Śliwiński, T.; Candeias, N.; Estevão, M. S.; Afonso, C. A. M.; André, V.; Sitarek, P.; Rijo, P.

Biomed. Pharmacother., 2024, 174, 116516 (DOI: 10.1016/j.biopha.2024.116516)

75. Cu-Catalyzed Tandem Oxidation-Intramolecular Cannizzaro Reaction of Biorenewables and Bioactive Molecules

Petkov, H.; Ravutsov, M. A.; Verganista, M. J.; Mitrev, Y. N.; Candeias, N. R.; Simeonov, S. P.

ChemSusChem, 2024, 17, e202400013 (DOI: 10.1002/cssc.202400013)

74. A novel EGFR Inhibitor, HNPMI regulates apoptosis and oncogenesis by modulating BCL-2/BAX and p53 in colon cancer

Kandhavelu, J.; Subramanian, K.; Naidoo, V.; Sebastianelli, G.; Doan, P.; Mani, S. K.; Yapislar, H.; Haciosmanoglu, E.; Arslan, L.; Ozer, S.; Thiyagarajan, R.; Candeias, N. R.; Penny, C.; Kandhavelu, M.; Murugesan, A.

Br. J. Pharmacol., 2024, 181, 107. (DOI: 10.1111/bph.16141 )

2023

73. Methanodibenzo[b,f][1,5]dioxocins as Novel Glutaminase Inhibitor with Anti-Glioblastoma Potential

Murugesab, A.; Kari, S.; Shrestha, A.; Assoah, B.; Saravan, K. M.; Murugesan, M.; Thuyagarajan, R.; Candeias, N. R.; Kandhavelu, M.

Cancers, 2023, 15, 1010. (DOI: 10.3390/cancers15041010)

72. Ru-catalyzed isomerization of Achmatowicz derivatives: a sustainable route to biorenewables and bioactive lactones

Dangalov, M.; Fernández-Figueiras, A.; Ravutsov, M. A.; Vakarelska, E.; Marinova, M. K.; Candeias, N. R.; Simeonov, S. P.

ACS Catal., 2023, 13, 1916. (DOI: 10.1021/acscatal.2c04867)

2022

71. Functionalized Cyclopentenes via the Formal [4+1] Cycloaddition of Photogenerated Siloxycarbenes from Acyl Silanes

Vale, J. R.; Gomes, R. F.; Afonso, C. A. M.; Candeias, N. R.

J. Org. Chem, 2022, 87, 8910. (DOI: 10.1021/acs.joc.2c00591)

70. C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators

Ntungwe, N. E.; Stojanov, S. J.; Duarte, N. M.; Candeias, N. R.; Díaz-Lanza, A. M.; Vágvölgyi, M.; Hunyadi, A.; Pešić, M.; Rijo, P.

ACS Med. Chem. Lett., 2022, 13, 674. (DOI: 10.1021/acsmedchemlett.1c00711)

69. Diketopyrrolo[3,4–c]pyrrole derivative as a promising ligand for the stabilization of G-quadruplex DNA structures

Ramos, C. V.; Almodôvar, V. A. S.; Candeias, N. R.; Santos, T.; Cruz, C.; Neves, M. G. P. M. S.; Tomé, A. C.

Bioorg. Chem., 2022, 122, 105703. (DOI: 10.1016/j.bioorg.2022.105703)

68. P2Y1 agonist HIC in combination with androgen receptor inhibitor abiraterone acetate impairs cell growth of prostate cancer

Le, H. T. T.; Murugesan, A.; Candeias, N. R.; Ramesh, T.; Yli-Harja, O.; Kandhavelu, M.

Apoptosis, 2022, 27, 283. (DOI: 10.1007/s10495-022-01716-1)

67. Protonation-induced fluorescence modulation of carbazole-based emitters

Taipale, E.; Durandin, N. A.; Salunke, J. K.; Candeias, N. R.; Ruoko, T.-P.; Ward. J. S.; Priimagi, A.; Rissanen, K.

Mater. Adv., 2022, 3, 1703. (DOI: 10.1039/D1MA00438G)

66. GPR17 signaling activation by CHBC agonist induced cell death via modulation of MAPK pathway in glioblastoma

Nguyen, P.; Doan, P.; Murugesan, A.; Ramesh, T.; Rimpilainen, T.; Candeias, N. R.; Yli-Harja, O.; Kandhavelu, M.

Life Sciences, 2022, 291, 120307. (DOI: 10.1016/j.lfs.2022.120307)

2021

65. Functional characterization of HIC, a P2Y1 agonist, as a p53 stabilizer for prostate cancer cell death induction

Le, H. T. T..; Murugesan, A.; Candeias, N. R.; Yli-Harja, O.; Kandhavelu, M.

Future Med. Chem., 2021, 13, 1845. (DOI: 10.4155/fmc-2021-0159)

64. Alkylaminophenol and GPR17 Agonist for Glioblastoma Therapy: A Combinational Approach for Enhanced Cell Death Activity

Doan, P.; Nguyen, P.; Murugesan, A.; Candeias, N. R.; Yli-Harja, O.; Kandhavelu, M.

Cells, 2021, 10, 1975. (DOI: 10.3390/cells10081975)

63. Synthesis and Preclinical Validation of Novel Indole Derivatives as a GPR17 Agonist for Glioblastoma Treatment

Nguyen, P.; Doan, P.; Rimpilainen, T.; Mani, S. K.; Murugesan, A.; Yli-Harja, O.; Candeias, N. R.; Kandhavelu, M.

J. Med. Chem. 2021, 64, 10908. (DOI: 10.1021/acs.jmedchem.1c00277)

62. Increased antibacterial properties of indoline-derived phenolic Mannich bases

Rimpilainen, T.; Nunes, A.; Calado, R.; Fernandes, A. S.; Andrade, J.; Ntungwe, E.;Spengler, G.; Szemerédi, N; Rodrigues, J.; Gomes, J. P.; Rijo, P.; Candeias, N. R.

Eur. J. Med. Chem. 2021, 220, 113459. (DOI: 10.1016/j.ejmech.2021.113459)

PrePrint (DOI: 10.26434/chemrxiv.14184929.v1)

61. O,O-Silyl Group Migrations in Quinic Acid Derivatives: An Opportunity for Divergent Synthesis

Holmstedt, S.; Efimov, A.; Candeias, N. R.

Org. Lett. 2021, 23, 3083. (DOI: 10.1021/acs.orglett.1c00755)

60. Modulation of Human Phenylalanine Hydroxylase by 3-Hydroxyquinolin-2(1H)-one Derivatives

P. R. Lopes; C. S. Tomé; R. Russo; R. Paterna; J. Leandro; N. R. Candeias; L. M. D. Gonçalves; M. Teixeira; P. M. F. Sousa; R. C. Guedes; J. B. Vicente; P. M. P. Gois; P. Leandro

Biomolecules 2021, 11, 462. (DOI: 10.3390/biom11030462)

2020

59. N-Substituted Phenothiazines as Environmentally Friendly Hole-Transporting Materials for Low-Cost and Highly Stable Halide Perovskite Solar Cells

J. Salunke; X. Guo; M. N. Liu; Z. H. Lin; N. R. Candeias; A. Priimagi; J. J. Chang; P. Vivo

ACS Omega 2020, 5, 23334-23342. (DOI: 10.1021/acsomega.0c03184)

58. Design and synthesis of novel quinic acid derivatives: in vitro cytotoxicity and anticancer effect on glioblastoma.

A. Murugesan; S. Holmstedt; K. C. Brown; A. Koivuporras; A. S. Macedo; N. Nguyen; P. Fonte; P. Rijo; O. Yli-Harja; N. R. Candeias; M. Kandhavelu

Future Med. Chem. 2020, 12, 1891-1910. (DOI: 10.4155/fmc-2020-0194)

57. Molecular Docking Studies of Royleanone Diterpenoids from Plectranthus spp. as P-Glycoprotein Inhibitors.

V. M. S. Isca; R. J. Ferreira; C. Garcia; C. M. Monteiro; J. Dinic; S. Holmstedt; V. Andre; M. Pesic; D. J. V. A. dos Santos; N. R. Candeias; C. A. M. Afonso; P. Rijo

ACS Med. Chem. Lett. 2020, 11, 839-845. (DOI: 10.1021/acsmedchemlett.9b00642)

56. Deoxygenative Divergent Synthesis: En Route to Quinic Acid Chirons

S. Holmstedt; L. George; A. Koivuporras; A. Valkonen; N. R. Candeias

Org. Lett. 2020, 22, 8370-8375. (DOI: 10.1021/acs.orglett.0c02995)

55. A concise synthesis of carbasugars isolated from Streptomyces lincolnensis

S. Holmstedt; N. R. Candeias

Tetrahedron 2020, 76, 131346. (DOI: 10.1016/j.tet.2020.131346)

In honour of Nuno Maulide recipient of the 2020 Tetrahedron Young Investigator Award

54. Royleanone Derivatives From Plectranthus spp. as a Novel Class of P-Glycoprotein Inhibitors

C. Garcia; V. M. S. Isca; F. Pereira; C. M. Monteiro; E. Ntungwe; F. Sousa; J. Dinic; S. Holmstedt; A. Roberto; A. Diaz-Lanza; C. P. Reis; M. Pesic; N. R. Candeias; R. J. Ferreira; N. Duarte; C. A. M. Afonso; P. Rijo

Frontiers in Pharmacol. 2020, 11, 557789. (DOI: 10.3389/fphar.2020.557789)

53. Glioblastoma Multiforme Stem Cell Cycle Arrest by Alkylaminophenol through the Modulation of EGFR and CSC Signaling Pathways

P. Doan; A. Musa; A. Murugesan; V. Sipila; N. R. Candeias; F. Emmert-Streib; P. Ruusuvuori; K. Granberg; O. Yli-Harja; M. Kandhavelu

Cells 2020, 9, 681. (DOI: 10.3390/cells9030681)

2019

52. In vitro anti-glioblastoma activity of L-valine derived boroxazolidones

A. Viswanathan; G. Sebastianelli; K. Brown; J. Raunio; V. Sipila; O. Yli-Harja; N. R. Candeias; M. Kandhavelu

Eur. J. Pharmacol. 2019, 854, 194-200. (DOI: 10.1016/j.ejphar.2019.04.020)

51. Battling Glioblastoma: A Novel Tyrosine Kinase Inhibitor with Multi-Dimensional Anti-Tumor Effect.

A. Viswanathan; A. Musa; A. Murugesan; J. R. Vale; C. A. M. Afonso; S. K. Mani; O. Yli-Harja; N. R. Candeias; M. Kandhavelu

Cells 2019, 8, 1624. (DOI: 10.3390/cells8121624)

50. Synthesis of silacyclopent-2-en-4-ols via intramolecular [2+2] photocycloaddition of benzoyl(allyl)silanes.

J. R. Vale; A. Valkonen; C. A. M. Afonso; N. R. Candeias

Org. Chem. Frontiers, 2019, 6, 3793-3798. (DOI: 10.1039/c9qo01028a)

49. Phenothiazine-Based Hole-Transporting Materials toward Eco-friendly Perovskite Solar Cells.

J. Salunke; X. Guo; Z. H. Lin; J. R. Vale; N. R. Candeias; M. Nyman; S. Dahlstrom; R. Osterbacka; A. Priimagi; J. J. Chang; P. Vivo

ACS Appl. Energy Mater. 2019, 2, 3021-3027. (DOI: 10.1021/acsaem.9b00408)

48. Synthesis and preclinical validation of novel P2Y1 receptor ligands as a potent anti-prostate cancer agent.

H. T. T. Le; T. Rimpilainen; S. K. Mani; A. Murugesan; O. Yli-Harja; N. R. Candeias; M. Kandhavelu

Sci. Rep. 2019, 9, 18938. (DOI: 10.1038/s41598-019-55194-8)

47. Zinc phthalocyanine activated by conventional indoor light makes a highly efficient antimicrobial material from regular cellulose.

N. E. Grammatikova; L. George; Z. Ahmed; N. R. Candeias; N. A. Durandin; A. Efimov

J. Mater. Chem. B 2019, 7, 4379-4384. (DOI: 10.1039/c9tb01095e)

46. Alkylaminophenol Induces G1/S Phase Cell Cycle Arrest in Glioblastoma Cells Through p53 and Cyclin-Dependent Kinase Signaling Pathway.

P. Doan; A. Musa; N. R. Candeias; F. Emmert-Streib; O. Yli-Harja; M. Kandhavelu

Front. Pharmacol. 2019, 10, 330. (DOI: 10.3389/fphar.2019.00330)

45. Pinacol-Derived Chlorohydrosilane in Metal-Free Reductive Amination for the Preparation of Tertiary Alkylphenolmethyl Amines.

B. Assoah; L. F. Veiros; N. R. Candeias

Org. Lett. 2019, 21, 1402-1406. (DOI: 10.1021/acs.orglett.9b00121)

44. Synthesis of 6,12-Disubstituted Methanodibenzo[b,f][1,5]dioxocins: Pyrrolidine Catalyzed Self-Condensation of 2 '-Hydroxyacetophenones.

B. Assoah; V. Riihonen; J. R. Vale; A. Valkonen; N. R. Candeias

Molecules 2019, 24, 2405. (DOI: 10.3390/molecules24132405)

2018

43. Decane-1,2-diol derivatives as potential antitumor agents for the treatment of glioblastoma.

A. Viswanathan; A. Zhurina; B. Assoah; A. Paakkunainen; A. Musa; D. Kute; K. M. Saravanan; O. Yli-Harja; N. R. Candeias; M. Kandhavelu

Eur. J. Pharmacol. 2018, 837, 105-116. (DOI: 10.1016/j.ejphar.2018.08.041)

42. Pot-Economy Autooxidative Condensation of 2-Aryl-2-lithio-1,3-dithianes.

J. R. Vale; T. Rimpilainen; E. Sievanen; K. Rissanen; C. A. M. Afonso; N. R. Candeias

J. Org. Chem. 2018, 83, 1948-1958. (DOI: 10.1021/acs.joc.7b02896)

41. Highly Efficient Energy Transfer Cassettes by Assembly of Boronic Acid Derived Salicylidenehydrazone Complexes.

F. M. F. Santos; Z. Dominguez; M. M. Alcaide; A. I. Matos; H. F. Florindo; N. R. Candeias; P. M. P. Gois; U. Pischel

Chemphotochem 2018, 2, 1038-1045. (DOI: 10.1002/cptc.201800150)

40. Halogen-Bond-Assisted Photoluminescence Modulation in Carbazole-Based Emitter.

J. K. Salunke; N. A. Durandin; T. P. Ruoko; N. R. Candeias; P. Vivo; E. Vuorimaa-Laukkanen; T. Laaksonen; A. Priimagi

Sci. Rep. 2018, 8, 14431. (DOI: 10.1038/s41598-018-32830-3 )

39. Aminobenzylated 4-Nitrophenols as Antibacterial Agents Obtained from 5-Nitrosalicylaldehyde through a Petasis Borono-Mannich Reaction.

T. Rimpilainen; J. Andrade; A. Nunes; E. Ntungwe; A. S. Fernandes; J. R. Vale; J. Rodrigues; J. P. Gomes; P. Rijo; N. R. Candeias

ACS Omega 2018, 3, 16191-16202. (DOI: 10.1021/acsomega.8b02381)

38. Production and Synthetic Modifications of Shikimic Acid.

N. R. Candeias; B. Assoah; S. P. Simeonov

Chem. Rev. 2018, 118, 10458-10550. (DOI: 10.1021/acs.chemrev.8b00350)

37. Lewis Base Catalyzed Intramolecular Reduction of Salicylaldehydes by Pinacol-Derived Chlorohydrosilane.

B. Assoah; J. R. Vale; E. Kalenius; L. F. Veiros; N. R. Candeias

Eur. J. Org. Chem. 2018, 2910-2917. (DOI: 10.1002/ejoc.201800544)

2017

36. Crystallisation-enhanced bulk hole mobility in phenothiazine-based organic semiconductors.

D. B. Shinde; J. K. Salunke; N. R. Candeias; F. Tinti; M. Gazzano; P. P. Wadgaonkar; A. Priimagi; N. Camaioni; P. Vivo

Sci. Rep. 2017, 7, 46268. (DOI: 10.1038/srep46268)

35. Base catalysed N-functionalisation of boroxazolidones.

J. Raunio; J. Mannoja; T. Nguyen; N. Ahmad; N. M. Kemppainen; R. G. Franzen; M. Kandhavelu; N. R. Candeias

RSC Adv. 2017, 7, 20620-20627. (DOI: 10.1039/c7ra03266h)

34. Synthesis of Phenol-derivatives and Biological Screening for Anticancer Activity.

A. Karjalainen; P. Doan; J. G. Chandraseelan; O. Sandberg; O. Yli-Harja; N. R. Candeias; M. Kandhavelu

Anti-Cancer Agents Med. Chem. 2017, 17, 1710-1720. (DOI: 10.2174/1871520617666170327142027 )

33. Effect of alkylaminophenols on growth inhibition and apoptosis of bone cancer cells.

P. Doan; T. Nguyen; O. Yli-Harja; N. R. Candeias; M. Kandhavelu

Eur. J. Pharm. Sci. 2017, 107, 208-216. (DOI:10.1016/j.ejps.2017.07.016)

2016

32. A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes).

F. M. F. Santos; J. N. Rosa; N. R. Candeias; C. P. Carvalho; A. I. Matos; A. E. Ventura; H. F. Florindo; L. C. Silva; U. Pischel; P. M. P. Gois

Chem. Eur. J. 2016, 22, 1631-1637. (DOI: 10.1002/chem.201503943)

31. Multicomponent Petasis-borono Mannich Preparation of Alkylaminophenols and Antimicrobial Activity Studies.

I. Neto; J. Andrade; A. S. Fernandes; C. P. Reis; J. K. Salunke; A. Priimagi; N. R. Candeias; P. Rijo

ChemMedChem 2016, 11, 2015-2023. (DOI: 10.1002/cmdc.201600244)

30. Synthesis and biological screening for cytotoxic activity of N-substituted indolines and morpholines.

P. Doan; A. Karjalainen; J. G. Chandraseelan; O. Sandberg; O. Yli-Harja; T. Rosholm; R. Franzen; N. R. Candeias; M. Kandhavelu

Eur. J. Med. Chem. 2016, 120, 296-303. (DOI: 10.1016/j.ejmech.2016.05.024)

29. Homologation Reaction of Ketones with Diazo Compounds.

N. R. Candeias; R. Paterna; P. M. P. Gois

Chem. Rev. 2016, 116, 2937-2981. (DOI: 10.1021/acs.chemrev.5b00381)

28. Biomass-Based and Oxidant-Free Preparation of Hydroquinone from Quinic Acid.

B. Assoah; L. F. Veiros; C. A. M. Afonso; N. R. Candeias

Eur. J. Org. Chem. 2016, 3856-3861. (DOI: 10.1002/ejoc.201600616 )

2015

27. Glycerol as an Efficient Medium for the Petasis Borono-Mannich Reaction.

T. Rosholm; P. M. P. Gois; R. Franzen; N. R. Candeias

Chemistryopen 2015, 4, 39-46. (DOI: 10.1002/open.201402066)

2014-2005

26. Ring-Expansion Reaction of Isatins with Ethyl Diazoacetate Catalyzed by Dirhodium(II)/DBU Metal-Organic System: En Route to Viridicatin Alkaloids.

R. Paterna; V. Andre; M. T. Duarte; L. F. Veiros; N. R. Candeias; P. M. P. Gois

Eur. J. Org. Chem. 2013, 6280-6290. (DOI: 10.1002/ejoc.201300796)

25. Short synthesis of the natural product 3 beta-hydroxy-labd-8(17)-en-15-oic acid via microbial transformation of labdanolic acid.

L. M. T. Frija; H. Garcia; C. Rodrigues; I. Martins; N. R. Candeias; V. Andre; M. T. Duarte; C. S. Pereira; C. A. M. Afonso

Phytochem. Lett. 2013, 6, 165-169. (DOI: 10.1016/j.phytol.2012.12.005)

24. Intramolecular C-H insertion catalyzed by dirhodium(II) complexes using CO2 as the reaction media.

M. E. Zakrzewska; P. M. S. D. Cal; N. R. Candeias; R. Bogel-Lukasik; C. A. M. Afonso; M. N. Ponte; P. M. P. Gois

Green Chem. Lett. Rev. 2012, 5, 211-240. (DOI: 10.1080/17518253.2011.620009)

23. Four-Component Assembly of Chiral N-B Heterocycles with a Natural Product-Like Framework.

F. Montalbano; N. R. Candeias; L. F. Veiros; V. Andre; M. T. Duarte; M. R. Bronze; R. Moreira; P. M. P. Gois

Org. Lett. 2012, 14, 988-991. (DOI: 10.1021/ol203224n)

22. A Sustainable Protocol for the Aqueous Multicomponent Petasis Borono-Mannich Reaction.

N. R. Candeias; R. Paterna; P. M. S. D. Cal; P. M. P. Gois

J. Chem. Educ. 2012, 89, 799-802. (DOI: 10.1021/ed200509q)

21. Asymmetric Intramolecular C-H Insertion of alpha-Diazoacetamides in Water by Dirhodium(II) Catalysts Derived from Natural Amino Acids.

N. R. Candeias; C. Carias; L. F. R. Gomes; V. Andre; M. T. Duarte; P. M. P. Gois; C. A. M. Afonso

Adv. Synth. Catal. 2012, 354, 2921-2927. (DOI: 10.1002/adsc.201200101)

20. Making expensive dirhodium(II) catalysts cheaper: Rh(II) recycling methods.

N. R. Candeias; C. A. M. Afonso; P. M. P. Gois

Org. Biomol. Chem. 2012, 10, 3357-3378. (DOI: 10.1039/c2ob06731e)

19. Construction of bispirooxindoles containing three quaternary stereocentres in a cascade using a single multifunctional organocatalyst.

B. Tan; N. R. Candeias; C. F. Barbas

Nature Chem. 2011, 3, 473-477. (DOI: 10.1038/NCHEM.1039)

18. Core-Structure-Motivated Design of a Phosphine-Catalyzed [3+2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles.

B. Tan; N. R. Candeias; C. F. Barbas

J. Am. Chem. Soc. 2011, 133, 4672-4675. (DOI: 10.1021/ja110147w)

17. Boronic Acids and Esters in the Petasis-Borono Mannich Multicomponent Reaction.

N. R. Candeias; F. Montalbano; P. M. S. D. Cal; P. M. P. Gois

Chem. Rev. 2010, 110, 6169-6193. (DOI: 10.1021/cr100108k)

16. NHC-Iron-Catalyzed Aerobic Oxidative Aromatic Esterification of Aldehydes using Boronic Acids.

J. N. Rosa; R. S. Reddy; N. R. Candeias; P. M. S. D. Cal; P. M. P. Gois

Org. Lett. 2010, 12, 2686-2689. (DOI: 10.1021/ol100302e)

15. New dirhodium complex with activity towards colorectal cancer.

R. F. M. Frade; N. R. Candeias; C. M. M. Duarte; V. Andre; M. T. Duarte; P. M. P. Gois; C. A. M. Afonso

Bioorg. Med. Chem. Lett. 2010, 20, 3413-3415. (DOI: 10.1016/j.bmcl.2010.04.002)

14. Water as the reaction medium for multicomponent reactions based on boronic acids.

N. R. Candeias; P. M. S. D. Cal; V. Andre; M. T. Duarte; L. F. Veiros; P. M. P. Gois

Tetrahedron 2010, 66, 2736-2745. (DOI: 10.1016/j.tet.2010.01.084)

13. Dimeric Quinidine-Catalyzed Enantioselective Aminooxygenation of Oxindoles: An Organocatalytic Approach to 3-Hydroxyoxindole Derivatives.

T. Bui; N. R. Candeias; C. F. Barbas

J. Am. Chem. Soc. 2010, 132, 5574-5575. (DOI: 10.1021/ja101032j)

12. Cyclization of Diazoacetamides Catalyzed by N-Heterocyclic Carbene Dirhodium(II) Complexes.

L. F. R. Gomes; A. F. Trindade; N. R. Candeias; L. F. Veiros; P. M. P. Gois; C. A. M. Afonso

Synthesis 2009, 3519-3526. (DOI: 10.1055/s-0029-1217005)

11. Water: A Suitable Medium for the Petasis Borono-Mannich Reaction.

N. R. Candeias; L. F. Veiros; C. A. M. Afonso; P. M. P. Gois

Eur. J. Org. Chem. 2009, 1859-1863. (DOI: 10.1002/ejoc.200900056)

10. More Sustainable Approaches for the Synthesis of N-Based Heterocycles.

N. R. Candeias; L. C. Branco; P. M. P. Gois; C. A. M. Afonso; A. F. Trindade

Chem. Rev. 2009, 109, 2703-2802. (DOI: 10.1021/cr800462w)

9. Developments in the Photochemistry of Diazo Compounds.

N. R. Candeias; C. A. M. Afonso

Cur. Org. Chem. 2009, 13, 763-787. (DOI: 10.2174/138527209788167231)

8. Intramolecular C-H insertion using NHC-di-rhodium(II) complexes: the influence of axial coordination.

L. F. R. Gomes; A. F. Trindade; N. R. Candeias; P. M. P. Gois; C. A. M. Afonso

Tetrahedron Lett. 2008, 49, 7372-7375. (DOI: 10.1016/j.tetlet.2008.10.054)

7. C-H carbene insertion of alfa-diazo acetamides by photolysis in non-conventional media.

N. R. Candeias; P. M. P. Gois; L. F. Veiros; C. A. M. Afonso

J. Org. Chem. 2008, 73, 5926-5932. (DOI: 10.1021/jo800980c)

6. Rhodium (II) carbene C-H insertion in water and catalyst reuse.

N. R. Candeias; P. M. P. Gois; C. A. M. Afonso

Quimica Nova 2007, 30, 1768-1772. (DOI: 10.1590/S0100-40422007000700047)

5. Efficient catalyst reuse by simple dissolution in non-conventional media.

C. A. M. Afonso; L. C. Branco; N. R. Candeias; P. M. P. Gois; N. M. T. Lourenco; N. M. M. Mateus; J. N. Rosa

Chem. Commun. 2007, 2669-2679. (DOI: 10.1039/b607483a)

4. Rh(II)-catalyzed intramolecular C-H insertion of diazo substrates in water: Scope and limitations.

N. R. Candeias; P. M. P. Gois; C. A. M. Afonso

J. Org. Chem. 2006, 71, 5489-5497. (DOI: 10.1021/jo060397a)

3. Rh(II) catalysed intramolecular C-H insertion of diazo substrates in water: a simple and efficient approach to catalyst reuse.

N. R. Candeias; P. M. P. Gois; C. A. M. Afonso

Chem. Commun. 2005, 391-393. (DOI: 10.1039/b414233k)

2. Preparation of non-fused heterocycles in zeolites and mesoporous materials.

N. R. Candeias; C. A. M. Afonso

J. Mol. Catal. A Chem. 2005, 242, 195-217. (DOI: 10.1016/j.molcata.2005.07.042)

1. Preparation of enantioselective enriched alpha-(dialkoxyphosphoryl) lactams via intramolecular C-H insertion with chiral dirhodium(II) catalysts.

P. M. P. Gois; N. R. Candeias; C. A. M. Afonso

J. Mol. Catal. A Chem. 2005, 227, 17-24. (DOI: 10.1016/j.molcata.2004.09.041)

Edited Books

Comprehensive Organic Chemistry Experiments for the Laboratory Classroom

C. A. M. Afonso; N. R. Candeias; D. P. Simão; A. F. Trindade; J. A. S. Coelho; B. Tan; R, Franzén (Eds.),

Royal Society of Chemistry, 2016 (ISBN 9781849739634).

Book Chapters

11. J. R. Castro; N. R. Candeias, The Wolff Rearrangement in Comprehensive Organic Synthesis III - Volume 3: Carbon-Carbon Bond Formation; Section Eds.: Marek, I.; Elsevier, 2024, (DOI: 10.1016/B978-0-323-96025-0.00081-8)

10. N. R. Candeias; H. M. T. Albuquerque, Diazo Reagents Mediated Homologations in Homologation Reactions. Reagents, Applications and Mechanisms; Pace, V. (Eds), Wiley-VCH, 2023, (DOI: 10.1002/9783527830237.ch1, ISBN 978-3-527-34815-2), 1-78.

9. N. R. Candeias; A. Efimov, Thiopyrans and their benzo derivatives. In Comprehensive Heterocyclic Chemistry IV; Nuno Maulide (Eds), Elsevier, 2022 (DOI: 10.1016/B978-0-12-818655-8.00020-2, ISBN: 978-0-12-818656-5), Vol. 7, 512-670.

8. N. R. Candeias, 4.2.4. 1,4-addition to α,β-unsaturated Carbonyl Compounds. In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom; Afonso, C. A. M.; Candeias, N. R.; Simão, D. P.; Trindade, A. F.; Coelho, J. A. S.; Tan, B.; Franzén, R. (Eds.), Royal Society of Chemistry, 2016, (ISBN 9781849739634), 420-423.

7. N. R. Candeias; R. Paterna; P. M. S. D. Cal, P. M. P. Gois, 4.2.5.4. Preparation of Phenylglycine and Hydroxymorpholine Derivatives Through a Petasis Borono–Mannich Reaction. In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom; Afonso, C. A. M.; Candeias, N. R.; Simão, D. P.; Trindade, A. F.; Coelho, J. A. S.; Tan, B.; Franzén, R. (Eds.), Royal Society of Chemistry, 2016, (ISBN 9781849739634), 439-442.

6. F. Siopa; N. R. Candeias; C. A. M. Afonso, 6.2. Synthesis of the Antitumoral Drug 2,4,6-Tris(dimethylamino)-1,3,5-triazine via Sequential Nucleophilic Substitution. In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom; Afonso, C. A. M.; Candeias, N. R.; Simão, D. P.; Trindade, A. F.; Coelho, J. A. S.; Tan, B.; Franzén, R. (Eds.), Royal Society of Chemistry, 2016 (ISBN 9781849739634), 535-538.

5. N. R. Candeias; P. M. P. Gois; C. A. M. Afonso, 17.9. Rhodium Carbene C–H Insertion in Water and Catalyst Reuse. In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom; Afonso, C. A. M.; Candeias, N. R.; Simão, D. P.; Trindade, A. F.; Coelho, J. A. S.; Tan, B.; Franzén, R. (Eds.), Royal Society of Chemistry, 2016 (ISBN 9781849739634), 898-902.

4. N. R. Candeias; A. F. Trindade; P. M. P. Gois; C. A. M. Afonso, 3.19 The Wolff Rearrangement in Comprehensive Organic Synthesis II - Volume 3: Carbon-Carbon Bond Formation; Eds. In Chief: Molander, G.; Knochel, P.; Elsevier, 2014 (978-0-08-097743-0).

3. Experiments #99 and #100 for the 100 Experiências de Química Orgânica (100 Experiments of Organic Chemistry); Afonso, C. A. M; Simão, D. P.; Ferreira, L. P.; Serra, M. E. S., Raposo, M. M. M.; IST Press, 2011 (ISBN 978- 989-8481-09-2).

2. C. A. M. Afonso; L. C. Branco; N. R. Candeias; P. M. P. Gois; N. M. T. Lourenço, N. M. M. Mateus; J. N. Rosa, More Sustainable Synthetic Organic Chemistry Approaches Based On Catalytic Reuse. In A Portrait of State-of-the-art research at the Technical University of Lisbon; M. S. Pereira, Ed.; Springer, 2007 (ISBN 978-1-4020-5689-5).

1. N. R. Candeias; P. M. P. Gois; L. C. Branco; C. A. M. Afonso, More sustainable methods for the synthesis of heterocycles. In Recent Research Developments in Heterocyclic Chemistry; T. M. V. D. P. Melo, Ed.; Research Signpost Publishers, 2007 (ISBN 81-308-0169-8).