Publications
Â
Peer reviewed Publications
2023
74. A novel EGFR Inhibitor, HNPMI regulates apoptosis and oncogenesis by modulating BCL-2/BAX and p53 in colon cancer
Kandhavelu, J.; Subramanian, K.; Naidoo, V.; Sebastianelli, G.; Doan, P.; Mani, S. K.; Yapislar, H.; Haciosmanoglu, E.; Arslan, L.; Ozer, S.; Thiyagarajan, R.; Candeias, N. R.; Penny, C.; Kandhavelu, M.; Murugesan, A.Â
Br. J. Pharmacol., 2024, 181, 107. (DOI: 10.1111/bph.16141 )
73. Methanodibenzo[b,f][1,5]dioxocins as Novel Glutaminase Inhibitor with Anti-Glioblastoma Potential
Murugesab, A.; Kari, S.; Shrestha, A.; Assoah, B.; Saravan, K. M.; Murugesan, M.; Thuyagarajan, R.; Candeias, N. R.; Kandhavelu, M.
Cancers, 2023, 15, 1010. (DOI: 10.3390/cancers15041010)
72. Ru-catalyzed isomerization of Achmatowicz derivatives: a sustainable route to biorenewables and bioactive lactones
Dangalov, M.; Fernández-Figueiras, A.; Ravutsov, M. A.; Vakarelska, E.; Marinova, M. K.; Candeias, N. R.; Simeonov, S. P.
ACS Catal., 2023, 13, 1916. (DOI: 10.1021/acscatal.2c04867)
2022
71. Functionalized Cyclopentenes via the Formal [4+1] Cycloaddition of Photogenerated Siloxycarbenes from Acyl Silanes
Vale, J. R.; Gomes, R. F.; Afonso, C. A. M.; Candeias, N. R.
J. Org. Chem, 2022, 87, 8910. (DOI: 10.1021/acs.joc.2c00591)
70. C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators
Ntungwe, N. E.; Stojanov, S. J.; Duarte, N. M.; Candeias, N. R.; DÃaz-Lanza, A. M.; Vágvölgyi, M.; Hunyadi, A.; PeÅ¡ić, M.; Rijo, P.Â
ACS Med. Chem. Lett., 2022, 13, 674. (DOI: 10.1021/acsmedchemlett.1c00711)
69. Diketopyrrolo[3,4–c]pyrrole derivative as a promising ligand for the stabilization of G-quadruplex DNA structures
Ramos, C. V.; Almodôvar, V. A. S.; Candeias, N. R.; Santos, T.; Cruz, C.; Neves, M. G. P. M. S.; Tomé, A. C.Â
Bioorg. Chem., 2022, 122, 105703. (DOI: 10.1016/j.bioorg.2022.105703)
68. P2Y1 agonist HIC in combination with androgen receptor inhibitor abiraterone acetate impairs cell growth of prostate cancer
Le, H. T. T.; Murugesan, A.; Candeias, N. R.; Ramesh, T.; Yli-Harja, O.; Kandhavelu, M.
Apoptosis, 2022, 27, 283. (DOI: 10.1007/s10495-022-01716-1)
67. Protonation-induced fluorescence modulation of carbazole-based emitters
Taipale, E.; Durandin, N. A.; Salunke, J. K.; Candeias, N. R.; Ruoko, T.-P.; Ward. J. S.; Priimagi, A.; Rissanen, K.
Mater. Adv., 2022, 3, 1703. (DOI: 10.1039/D1MA00438G)
66. GPR17 signaling activation by CHBC agonist induced cell death via modulation of MAPK pathway in glioblastoma
Nguyen, P.; Doan, P.; Murugesan, A.; Ramesh, T.; Rimpilainen, T.; Candeias, N. R.; Yli-Harja, O.; Kandhavelu, M.
Life Sciences, 2022, 291, 120307. (DOI: 10.1016/j.lfs.2022.120307)
2021
65. Functional characterization of HIC, a P2Y1 agonist, as a p53 stabilizer for prostate cancer cell death induction
Le, H. T. T..; Murugesan, A.; Candeias, N. R.; Yli-Harja, O.; Kandhavelu, M.
Future Med. Chem., 2021, 13, 1845. (DOI: 10.4155/fmc-2021-0159)
64. Alkylaminophenol and GPR17 Agonist for Glioblastoma Therapy: A Combinational Approach for Enhanced Cell Death Activity
Doan, P.; Nguyen, P.; Murugesan, A.; Candeias, N. R.; Yli-Harja, O.; Kandhavelu, M.
Cells, 2021, 10, 1975. (DOI: 10.3390/cells10081975)
63. Synthesis and Preclinical Validation of Novel Indole Derivatives as a GPR17 Agonist for Glioblastoma Treatment
Nguyen, P.; Doan, P.; Rimpilainen, T.; Mani, S. K.; Murugesan, A.; Yli-Harja, O.; Candeias, N. R.; Kandhavelu, M.
J. Med. Chem. 2021, 64, 10908. (DOI: 10.1021/acs.jmedchem.1c00277)
62. Increased antibacterial properties of indoline-derived phenolic Mannich bases
Rimpilainen, T.; Nunes, A.; Calado, R.; Fernandes, A. S.; Andrade, J.; Ntungwe, E.;Spengler, G.; Szemerédi, N; Rodrigues, J.; Gomes, J. P.; Rijo, P.; Candeias, N. R.
Eur. J. Med. Chem. 2021, 220, 113459. (DOI: 10.1016/j.ejmech.2021.113459)
PrePrint (DOI: 10.26434/chemrxiv.14184929.v1)
61. O,O-Silyl Group Migrations in Quinic Acid Derivatives: An Opportunity for Divergent Synthesis
Holmstedt, S.; Efimov, A.; Candeias, N. R.
Org. Lett. 2021, 23, 3083. (DOI: 10.1021/acs.orglett.1c00755)
60. Modulation of Human Phenylalanine Hydroxylase by 3-Hydroxyquinolin-2(1H)-one Derivatives
P. R. Lopes; C. S. Tomé; R. Russo; R. Paterna; J. Leandro; N. R. Candeias; L. M. D. Gonçalves; M. Teixeira; P. M. F. Sousa; R. C. Guedes; J. B. Vicente; P. M. P. Gois; P. Leandro
Biomolecules 2021, 11, 462. (DOI: 10.3390/biom11030462)
2020
59. N-Substituted Phenothiazines as Environmentally Friendly Hole-Transporting Materials for Low-Cost and Highly Stable Halide Perovskite Solar Cells
 J. Salunke; X. Guo; M. N. Liu; Z. H. Lin; N. R. Candeias; A. Priimagi; J. J. Chang; P. Vivo
ACS Omega 2020, 5, 23334-23342. (DOI: 10.1021/acsomega.0c03184)
58. Design and synthesis of novel quinic acid derivatives: in vitro cytotoxicity and anticancer effect on glioblastoma.Â
A. Murugesan; S. Holmstedt; K. C. Brown; A. Koivuporras; A. S. Macedo; N. Nguyen; P. Fonte; P. Rijo; O. Yli-Harja; N. R. Candeias; M. Kandhavelu
Future Med. Chem. 2020, 12, 1891-1910. (DOI: 10.4155/fmc-2020-0194)Â
57. Molecular Docking Studies of Royleanone Diterpenoids from Plectranthus spp. as P-Glycoprotein Inhibitors.Â
V. M. S. Isca; R. J. Ferreira; C. Garcia; C. M. Monteiro; J. Dinic; S. Holmstedt; V. Andre; M. Pesic; D. J. V. A. dos Santos; N. R. Candeias; C. A. M. Afonso; P. Rijo
ACS Med. Chem. Lett. 2020, 11, 839-845. (DOI: 10.1021/acsmedchemlett.9b00642)
56. Deoxygenative Divergent Synthesis: En Route to Quinic Acid Chirons
S. Holmstedt; L. George; A. Koivuporras; A. Valkonen; N. R. Candeias
Org. Lett. 2020, 22, 8370-8375. (DOI: 10.1021/acs.orglett.0c02995)
55. A concise synthesis of carbasugars isolated from Streptomyces lincolnensis
S. Holmstedt; N. R. CandeiasÂ
Tetrahedron 2020, 76, 131346. (DOI: 10.1016/j.tet.2020.131346)
In honour of Nuno Maulide recipient of the 2020 Tetrahedron Young Investigator Award Â
54. Royleanone Derivatives From Plectranthus spp. as a Novel Class of P-Glycoprotein Inhibitors
C. Garcia; V. M. S. Isca; F. Pereira; C. M. Monteiro; E. Ntungwe; F. Sousa; J. Dinic; S. Holmstedt; A. Roberto; A. Diaz-Lanza; C. P. Reis; M. Pesic; N. R. Candeias; R. J. Ferreira; N. Duarte; C. A. M. Afonso; P. Rijo
Frontiers in Pharmacol. 2020, 11, 557789. (DOI: 10.3389/fphar.2020.557789)
53. Glioblastoma Multiforme Stem Cell Cycle Arrest by Alkylaminophenol through the Modulation of EGFR and CSC Signaling Pathways
P. Doan; A. Musa; A. Murugesan; V. Sipila; N. R. Candeias; F. Emmert-Streib; P. Ruusuvuori; K. Granberg; O. Yli-Harja; M. Kandhavelu
Cells 2020, 9, 681. (DOI: 10.3390/cells9030681)
2019
52. In vitro anti-glioblastoma activity of L-valine derived boroxazolidones
A. Viswanathan; G. Sebastianelli; K. Brown; J. Raunio; V. Sipila; O. Yli-Harja; N. R. Candeias; M. Kandhavelu
Eur. J. Pharmacol. 2019, 854, 194-200. (DOI: 10.1016/j.ejphar.2019.04.020)
51. Battling Glioblastoma: A Novel Tyrosine Kinase Inhibitor with Multi-Dimensional Anti-Tumor Effect.
A. Viswanathan; A. Musa; A. Murugesan; J. R. Vale; C. A. M. Afonso; S. K. Mani; O. Yli-Harja; N. R. Candeias; M. Kandhavelu
Cells 2019, 8, 1624. (DOI: 10.3390/cells8121624)
50. Synthesis of silacyclopent-2-en-4-ols via intramolecular [2+2] photocycloaddition of benzoyl(allyl)silanes.
J. R. Vale; A. Valkonen; C. A. M. Afonso; N. R. Candeias
Org. Chem. Frontiers, 2019, 6, 3793-3798. (DOI: 10.1039/c9qo01028a)
49. Phenothiazine-Based Hole-Transporting Materials toward Eco-friendly Perovskite Solar Cells.
J. Salunke; X. Guo; Z. H. Lin; J. R. Vale; N. R. Candeias; M. Nyman; S. Dahlstrom; R. Osterbacka; A. Priimagi; J. J. Chang; P. Vivo
ACS Appl. Energy Mater. 2019, 2, 3021-3027. (DOI: 10.1021/acsaem.9b00408)
48. Synthesis and preclinical validation of novel P2Y1 receptor ligands as a potent anti-prostate cancer agent.
H. T. T. Le; T. Rimpilainen; S. K. Mani; A. Murugesan; O. Yli-Harja; N. R. Candeias; M. Kandhavelu
Sci. Rep. 2019, 9, 18938. (DOI: 10.1038/s41598-019-55194-8)
47. Zinc phthalocyanine activated by conventional indoor light makes a highly efficient antimicrobial material from regular cellulose.
N. E. Grammatikova; L. George; Z. Ahmed; N. R. Candeias; N. A. Durandin; A. Efimov
J. Mater. Chem. B 2019, 7, 4379-4384. (DOI: 10.1039/c9tb01095e)
46. Alkylaminophenol Induces G1/S Phase Cell Cycle Arrest in Glioblastoma Cells Through p53 and Cyclin-Dependent Kinase Signaling Pathway.
P. Doan; A. Musa; N. R. Candeias; F. Emmert-Streib; O. Yli-Harja; M. Kandhavelu
Front. Pharmacol. 2019, 10, 330. (DOI: 10.3389/fphar.2019.00330)
45. Pinacol-Derived Chlorohydrosilane in Metal-Free Reductive Amination for the Preparation of Tertiary Alkylphenolmethyl Amines.
B. Assoah; L. F. Veiros; N. R. Candeias
Org. Lett. 2019, 21, 1402-1406. (DOI: 10.1021/acs.orglett.9b00121)
44. Synthesis of 6,12-Disubstituted Methanodibenzo[b,f][1,5]dioxocins: Pyrrolidine Catalyzed Self-Condensation of 2 '-Hydroxyacetophenones.
B. Assoah; V. Riihonen; J. R. Vale; A. Valkonen; N. R. Candeias
Molecules 2019, 24, 2405. (DOI: 10.3390/molecules24132405)
2018
43. Decane-1,2-diol derivatives as potential antitumor agents for the treatment of glioblastoma.
A. Viswanathan; A. Zhurina; B. Assoah; A. Paakkunainen; A. Musa; D. Kute; K. M. Saravanan; O. Yli-Harja; N. R. Candeias; M. Kandhavelu
Eur. J. Pharmacol. 2018, 837, 105-116. (DOI: 10.1016/j.ejphar.2018.08.041)
42. Pot-Economy Autooxidative Condensation of 2-Aryl-2-lithio-1,3-dithianes.
J. R. Vale; T. Rimpilainen; E. Sievanen; K. Rissanen; C. A. M. Afonso; N. R. Candeias
J. Org. Chem. 2018, 83, 1948-1958. (DOI: 10.1021/acs.joc.7b02896)
41. Highly Efficient Energy Transfer Cassettes by Assembly of Boronic Acid Derived Salicylidenehydrazone Complexes.
F. M. F. Santos; Z. Dominguez; M. M. Alcaide; A. I. Matos; H. F. Florindo; N. R. Candeias; P. M. P. Gois; U. Pischel
Chemphotochem 2018, 2, 1038-1045. (DOI: 10.1002/cptc.201800150)
40. Halogen-Bond-Assisted Photoluminescence Modulation in Carbazole-Based Emitter.
J. K. Salunke; N. A. Durandin; T. P. Ruoko; N. R. Candeias; P. Vivo; E. Vuorimaa-Laukkanen; T. Laaksonen; A. Priimagi
Sci. Rep. Â 2018, 8, 14431. (DOI: 10.1038/s41598-018-32830-3 )
39. Aminobenzylated 4-Nitrophenols as Antibacterial Agents Obtained from 5-Nitrosalicylaldehyde through a Petasis Borono-Mannich Reaction.
T. Rimpilainen; J. Andrade; A. Nunes; E. Ntungwe; A. S. Fernandes; J. R. Vale; J. Rodrigues; J. P. Gomes; P. Rijo; N. R. Candeias
ACS Omega 2018, 3, 16191-16202. (DOI: 10.1021/acsomega.8b02381)
38. Production and Synthetic Modifications of Shikimic Acid.
N. R. Candeias; B. Assoah; S. P. Simeonov
Chem. Rev. 2018, 118, 10458-10550. (DOI: 10.1021/acs.chemrev.8b00350)
37. Lewis Base Catalyzed Intramolecular Reduction of Salicylaldehydes by Pinacol-Derived Chlorohydrosilane.
B. Assoah; J. R. Vale; E. Kalenius; L. F. Veiros; N. R. Candeias
Eur. J. Org. Chem. 2018, 2910-2917. (DOI: 10.1002/ejoc.201800544)
2017
36. Crystallisation-enhanced bulk hole mobility in phenothiazine-based organic semiconductors.
D. B. Shinde; J. K. Salunke; N. R. Candeias; F. Tinti; M. Gazzano; P. P. Wadgaonkar; A. Priimagi; N. Camaioni; P. Vivo
Sci. Rep. 2017, 7, 46268. (DOI: 10.1038/srep46268)Â Â
35. Base catalysed N-functionalisation of boroxazolidones.
J. Raunio; J. Mannoja; T. Nguyen; N. Ahmad; N. M. Kemppainen; R. G. Franzen; M. Kandhavelu; N. R. Candeias
RSC Adv. 2017, 7, 20620-20627. (DOI: 10.1039/c7ra03266h)Â
34. Synthesis of Phenol-derivatives and Biological Screening for Anticancer Activity.
A. Karjalainen; P. Doan; J. G. Chandraseelan; O. Sandberg; O. Yli-Harja; N. R. Candeias; M. Kandhavelu
Anti-Cancer Agents Med. Chem. 2017, 17, 1710-1720. (DOI: 10.2174/1871520617666170327142027 )Â
33. Effect of alkylaminophenols on growth inhibition and apoptosis of bone cancer cells.
P. Doan; T. Nguyen; O. Yli-Harja; N. R. Candeias; M. Kandhavelu
Eur. J. Pharm. Sci. 2017, 107, 208-216. (DOI:10.1016/j.ejps.2017.07.016)
2016
32. A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes).
F. M. F. Santos; J. N. Rosa; N. R. Candeias; C. P. Carvalho; A. I. Matos; A. E. Ventura; H. F. Florindo; L. C. Silva; U. Pischel; P. M. P. Gois
Chem. Eur. J. 2016, 22, 1631-1637. (DOI: 10.1002/chem.201503943)
31. Multicomponent Petasis-borono Mannich Preparation of Alkylaminophenols and Antimicrobial Activity Studies.
I. Neto; J. Andrade; A. S. Fernandes; C. P. Reis; J. K. Salunke; A. Priimagi; N. R. Candeias; P. Rijo
ChemMedChem 2016, 11, 2015-2023. (DOI: 10.1002/cmdc.201600244)
30. Synthesis and biological screening for cytotoxic activity of N-substituted indolines and morpholines.
P. Doan; A. Karjalainen; J. G. Chandraseelan; O. Sandberg; O. Yli-Harja; T. Rosholm; R. Franzen; N. R. Candeias; M. Kandhavelu
Eur. J. Med. Chem. 2016, 120, 296-303. (DOI: 10.1016/j.ejmech.2016.05.024)
29. Homologation Reaction of Ketones with Diazo Compounds.
N. R. Candeias; R. Paterna; P. M. P. Gois
Chem. Rev. 2016, 116, 2937-2981. (DOI: 10.1021/acs.chemrev.5b00381)
28. Biomass-Based and Oxidant-Free Preparation of Hydroquinone from Quinic Acid.
B. Assoah; L. F. Veiros; C. A. M. Afonso; N. R. Candeias
Eur. J. Org. Chem. 2016, 3856-3861. (DOI: 10.1002/ejoc.201600616 )
2015
27. Glycerol as an Efficient Medium for the Petasis Borono-Mannich Reaction.
T. Rosholm; P. M. P. Gois; R. Franzen; N. R. Candeias
Chemistryopen 2015, 4, 39-46. (DOI: 10.1002/open.201402066)
2014-2005
26. Ring-Expansion Reaction of Isatins with Ethyl Diazoacetate Catalyzed by Dirhodium(II)/DBU Metal-Organic System: En Route to Viridicatin Alkaloids.
R. Paterna; V. Andre; M. T. Duarte; L. F. Veiros; N. R. Candeias; P. M. P. Gois
Eur. J. Org. Chem. 2013, 6280-6290. (DOI: 10.1002/ejoc.201300796)
25. Short synthesis of the natural product 3 beta-hydroxy-labd-8(17)-en-15-oic acid via microbial transformation of labdanolic acid.
L. M. T. Frija; H. Garcia; C. Rodrigues; I. Martins; N. R. Candeias; V. Andre; M. T. Duarte; C. S. Pereira; C. A. M. Afonso
Phytochem. Lett. 2013, 6, 165-169. (DOI: 10.1016/j.phytol.2012.12.005)
24. Intramolecular C-H insertion catalyzed by dirhodium(II) complexes using CO2 as the reaction media.
M. E. Zakrzewska; P. M. S. D. Cal; N. R. Candeias; R. Bogel-Lukasik; C. A. M. Afonso; M. N. Ponte; P. M. P. Gois
Green Chem. Lett. Rev. 2012, 5, 211-240. (DOI: 10.1080/17518253.2011.620009)
23. Four-Component Assembly of Chiral N-B Heterocycles with a Natural Product-Like Framework.
F. Montalbano; N. R. Candeias; L. F. Veiros; V. Andre; M. T. Duarte; M. R. Bronze; R. Moreira; P. M. P. Gois
Org. Lett. 2012, 14, 988-991. (DOI: 10.1021/ol203224n)
22. A Sustainable Protocol for the Aqueous Multicomponent Petasis Borono-Mannich Reaction.
N. R. Candeias; R. Paterna; P. M. S. D. Cal; P. M. P. Gois
J. Chem. Educ. 2012, 89, 799-802. (DOI: 10.1021/ed200509q)
21. Asymmetric Intramolecular C-H Insertion of alpha-Diazoacetamides in Water by Dirhodium(II) Catalysts Derived from Natural Amino Acids.
N. R. Candeias; C. Carias; L. F. R. Gomes; V. Andre; M. T. Duarte; P. M. P. Gois; C. A. M. Afonso
Adv. Synth. Catal. 2012, 354, 2921-2927. (DOI: 10.1002/adsc.201200101)
20. Making expensive dirhodium(II) catalysts cheaper: Rh(II) recycling methods.
N. R. Candeias; C. A. M. Afonso; P. M. P. Gois
Org. Biomol. Chem. 2012, 10, 3357-3378. (DOI: 10.1039/c2ob06731e)
19. Construction of bispirooxindoles containing three quaternary stereocentres in a cascade using a single multifunctional organocatalyst.
B. Tan; N. R. Candeias; C. F. Barbas
Nature Chem. 2011, 3, 473-477. (DOI: 10.1038/NCHEM.1039)
18. Core-Structure-Motivated Design of a Phosphine-Catalyzed [3+2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles.
B. Tan; N. R. Candeias; C. F. Barbas
J. Am. Chem. Soc. 2011, 133, 4672-4675. (DOI: 10.1021/ja110147w)
17. Boronic Acids and Esters in the Petasis-Borono Mannich Multicomponent Reaction.
N. R. Candeias; F. Montalbano; P. M. S. D. Cal; P. M. P. Gois
Chem. Rev. 2010, 110, 6169-6193. (DOI: 10.1021/cr100108k)
16. NHC-Iron-Catalyzed Aerobic Oxidative Aromatic Esterification of Aldehydes using Boronic Acids.
J. N. Rosa; R. S. Reddy; N. R. Candeias; P. M. S. D. Cal; P. M. P. Gois
Org. Lett. 2010, 12, 2686-2689. (DOI: 10.1021/ol100302e)
15. New dirhodium complex with activity towards colorectal cancer.
R. F. M. Frade; N. R. Candeias; C. M. M. Duarte; V. Andre; M. T. Duarte; P. M. P. Gois; C. A. M. Afonso
Bioorg. Med. Chem. Lett. 2010, 20, 3413-3415. (DOI: 10.1016/j.bmcl.2010.04.002)
14. Water as the reaction medium for multicomponent reactions based on boronic acids.
N. R. Candeias; P. M. S. D. Cal; V. Andre; M. T. Duarte; L. F. Veiros; P. M. P. Gois
Tetrahedron 2010, 66, 2736-2745. (DOI: 10.1016/j.tet.2010.01.084)
13. Dimeric Quinidine-Catalyzed Enantioselective Aminooxygenation of Oxindoles: An Organocatalytic Approach to 3-Hydroxyoxindole Derivatives.
T. Bui; N. R. Candeias; C. F. Barbas
J. Am. Chem. Soc. 2010, 132, 5574-5575. (DOI: 10.1021/ja101032j)
12. Cyclization of Diazoacetamides Catalyzed by N-Heterocyclic Carbene Dirhodium(II) Complexes.
L. F. R. Gomes; A. F. Trindade; N. R. Candeias; L. F. Veiros; P. M. P. Gois; C. A. M. Afonso
Synthesis 2009, 3519-3526. (DOI: 10.1055/s-0029-1217005)
11. Water: A Suitable Medium for the Petasis Borono-Mannich Reaction.
N. R. Candeias; L. F. Veiros; C. A. M. Afonso; P. M. P. Gois
Eur. J. Org. Chem. 2009, 1859-1863. (DOI: 10.1002/ejoc.200900056)
10. More Sustainable Approaches for the Synthesis of N-Based Heterocycles.
N. R. Candeias; L. C. Branco; P. M. P. Gois; C. A. M. Afonso; A. F. Trindade
Chem. Rev. 2009, 109, 2703-2802. (DOI: 10.1021/cr800462w)
9. Developments in the Photochemistry of Diazo Compounds.
N. R. Candeias; C. A. M. Afonso
Cur. Org. Chem. 2009, 13, 763-787. (DOI: 10.2174/138527209788167231)
8. Intramolecular C-H insertion using NHC-di-rhodium(II) complexes: the influence of axial coordination.
L. F. R. Gomes; A. F. Trindade; N. R. Candeias; P. M. P. Gois; C. A. M. Afonso
Tetrahedron Lett. 2008, 49, 7372-7375. (DOI: 10.1016/j.tetlet.2008.10.054)
7. C-H carbene insertion of alfa-diazo acetamides by photolysis in non-conventional media.
N. R. Candeias; P. M. P. Gois; L. F. Veiros; C. A. M. Afonso
J. Org. Chem. 2008, 73, 5926-5932. (DOI: 10.1021/jo800980c)
6. Rhodium (II) carbene C-H insertion in water and catalyst reuse.
N. R. Candeias; P. M. P. Gois; C. A. M. Afonso
Quimica Nova 2007, 30, 1768-1772. (DOI: 10.1590/S0100-40422007000700047)
5. Efficient catalyst reuse by simple dissolution in non-conventional media.
C. A. M. Afonso; L. C. Branco; N. R. Candeias; P. M. P. Gois; N. M. T. Lourenco; N. M. M. Mateus; J. N. Rosa
Chem. Commun. 2007, 2669-2679. (DOI: 10.1039/b607483a)
4. Rh(II)-catalyzed intramolecular C-H insertion of diazo substrates in water: Scope and limitations.
N. R. Candeias; P. M. P. Gois; C. A. M. Afonso
J. Org. Chem. 2006, 71, 5489-5497. (DOI: 10.1021/jo060397a)
3. Rh(II) catalysed intramolecular C-H insertion of diazo substrates in water: a simple and efficient approach to catalyst reuse.
N. R. Candeias; P. M. P. Gois; C. A. M. Afonso
Chem. Commun. 2005, 391-393. (DOI: 10.1039/b414233k)
2. Preparation of non-fused heterocycles in zeolites and mesoporous materials.
N. R. Candeias; C. A. M. Afonso
J. Mol. Catal. A Chem. 2005, 242, 195-217. (DOI: 10.1016/j.molcata.2005.07.042)
1. Preparation of enantioselective enriched alpha-(dialkoxyphosphoryl) lactams via intramolecular C-H insertion with chiral dirhodium(II) catalysts.
P. M. P. Gois; N. R. Candeias; C. A. M. Afonso
J. Mol. Catal. A Chem. 2005, 227, 17-24. (DOI: 10.1016/j.molcata.2004.09.041)
Edited Books
Comprehensive Organic Chemistry Experiments for the Laboratory ClassroomÂ
C. A. M. Afonso; N. R. Candeias; D. P. Simão; A. F. Trindade; J. A. S. Coelho; B. Tan; R, Franzén (Eds.),Â
Royal Society of Chemistry, 2016Â (ISBN 9781849739634).
Book Chapters
10. N. R. Candeias; H. M. T. Albuquerque, Diazo Reagents Mediated Homologations in Homologation Reactions. Reagents, Applications and Mechanisms; Pace, V. (Eds), Wiley-VCH, 2023, (DOI: 10.1002/9783527830237.ch1, ISBN 978-3-527-34815-2), 1-78.Â
9. N. R. Candeias; A. Efimov, Thiopyrans and their benzo derivatives. In Comprehensive Heterocyclic Chemistry IV; Nuno Maulide (Eds), Elsevier, 2022 (DOI: 10.1016/B978-0-12-818655-8.00020-2, ISBN: 978-0-12-818656-5), Vol. 7, 512-670.Â
8. N. R. Candeias, 4.2.4. 1,4-addition to α,β-unsaturated Carbonyl Compounds. In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom; Afonso, C. A. M.; Candeias, N. R.; Simão, D. P.; Trindade, A. F.; Coelho, J. A. S.; Tan, B.; Franzén, R. (Eds.), Royal Society of Chemistry, 2016, (ISBN 9781849739634), 420-423.
7. N. R. Candeias; R. Paterna; P. M. S. D. Cal, P. M. P. Gois, 4.2.5.4. Preparation of Phenylglycine and Hydroxymorpholine Derivatives Through a Petasis Borono–Mannich Reaction. In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom; Afonso, C. A. M.; Candeias, N. R.; Simão, D. P.; Trindade, A. F.; Coelho, J. A. S.; Tan, B.; Franzén, R. (Eds.), Royal Society of Chemistry, 2016, (ISBN 9781849739634), 439-442.
6. F. Siopa; N. R. Candeias; C. A. M. Afonso, 6.2. Synthesis of the Antitumoral Drug 2,4,6-Tris(dimethylamino)-1,3,5-triazine via Sequential Nucleophilic Substitution. In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom; Afonso, C. A. M.; Candeias, N. R.; Simão, D. P.; Trindade, A. F.; Coelho, J. A. S.; Tan, B.; Franzén, R. (Eds.), Royal Society of Chemistry, 2016 (ISBN 9781849739634), 535-538.
5. N. R. Candeias; P. M. P. Gois; C. A. M. Afonso, 17.9. Rhodium Carbene C–H Insertion in Water and Catalyst Reuse. In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom; Afonso, C. A. M.; Candeias, N. R.; Simão, D. P.; Trindade, A. F.; Coelho, J. A. S.; Tan, B.; Franzén, R. (Eds.), Royal Society of Chemistry, 2016 (ISBN 9781849739634), 898-902.
4. N. R. Candeias; A. F. Trindade; P. M. P. Gois; C. A. M. Afonso, 3.19 The Wolff Rearrangement in Comprehensive Organic Synthesis II - Volume 3: Carbon-Carbon Bond Formation; Eds. In Chief: Molander, G.; Knochel, P.; Elsevier, 2014 (978-0-08-097743-0).
3. Experiments #99 and #100 for the 100 Experiências de QuÃmica Orgânica (100 Experiments of Organic Chemistry); Afonso, C. A. M; Simão, D. P.; Ferreira, L. P.; Serra, M. E. S., Raposo, M. M. M.; IST Press, 2011 (ISBN 978- 989-8481-09-2).
2. C. A. M. Afonso; L. C. Branco; N. R. Candeias; P. M. P. Gois; N. M. T. Lourenço, N. M. M. Mateus; J. N. Rosa, More Sustainable Synthetic Organic Chemistry Approaches Based On Catalytic Reuse. In A Portrait of State-of-the-art research at the Technical University of Lisbon; M. S. Pereira, Ed.; Springer, 2007 (ISBN 978-1-4020-5689-5).Â
1. N. R. Candeias; P. M. P. Gois; L. C. Branco; C. A. M. Afonso, More sustainable methods for the synthesis of heterocycles. In Recent Research Developments in Heterocyclic Chemistry; T. M. V. D. P. Melo, Ed.; Research Signpost Publishers, 2007 (ISBN 81-308-0169-8).