Curriculum vitae

Name: Vera Mónica Almeida Afreixo

Nationality: Portuguese
Hometown: Ovar
Date of birth: May 24, 1977
Marital Status: Married

Email: vera_at_ua.pt

 

Academic degrees, intituitions,study topics

  • October  2008 – Ph. D., University of Aveiro, Electrotechnics Engineering.
  • January  2003 – M. Sc., University of Aveiro, Matemathics and Applications: Statistic and Operational Investigation.
  •  June 2000 – Graduation, University of Aveiro, Matemathics.

 

Current positions, instituition, start date

  •  Assistant professor, Department of Mathematics – University of Aveiro, November  2010, http://www.mat.ua.pt/.
  • Member ofProbability and Satistics Group from The Center for Research & Development in Mathematics and Applications (CIDMA) –  University of Aveiro, March 2009, http://cidma.mat.ua.pt/.
  • MSc Medical Statistics Course Director
  • Collaborator of Institute of Electronics and Telematics Engineering of Aveiro (IEETA) –  University of Aveiro, January 2011, http://wiki.ieeta.pt/wiki/index.php/Main_Page

 

Main research area

  • Probability and Satistics
    • Biostatistics
    • Genomic statistics
    • Meta-analysis
  • Sinal processing
    • Computational biology

 

 

Grants and scolarships, instituition, starting date, duration

  •  Ph.D. Student, Fundação para a Ciência e Tecnologia (FCT),  May 2005, 36 months.
  • Research Grant - Project “New bioinformatics tool for genome analysis unvails new rules governing speed and accuracy of mRNA decoding” , Fundação para a Ciência e Tecnologia - University of Aveiro, November 2002, 24 months.
  • Research Grant, Institute of Electronics and Telematics Engineering of Aveiro (IEETA), February  2002, 6 months.
  • M.Sc. Grant, University of Aveiro,  November  2000, 12 months.

 

Previous positions, instituition, starting date, duration

  • Teaching Assistant, Mathematic Department – University of Aveiro, 4 years.
  • Monitor, mathematic department – University of Aveiro, October 2001, 36 months.
  • Teaching Trainee, Secondary school Jose Estêvão (Escola Secundária José Estêvão), September 1999, 12 months.

 


List of Publications

Thesis and dissertations

Monographs

  • V. Afreixo, "Relações e Funções - modelos para a BDAAv", Monographs. University of Aveiro, May 2000.

 

Some publications

 

1.      Ana Helena Tavares, Jakob Raymaekers, Peter Rousseeuw, Paula Brito and Vera Afreixo “Clustering genomic words in human DNA using peaks and trends of distributions” Statistics and Computing

https://doi.org/10.1007/s11634-019-00362-x

2.      Afreixo V, Cruz S, Freitas A, Hernandez (2019) M. Meta-Analysis of a Very Low Proportion Through Adjusted Wald Confidence Intervals. Open Access Biostatistics & Bioinformatics 2(4). OABB.000545.2019.

https://doi.org/10.31031/OABB.2019.02.000545  

3.      Antunes, P., Esteves, D., Nunes, C., Amarelo, A., Fonseca-Moutinho, J., Afreixo, V., ... & Joaquim, A. (2019). Effects of physical exercise on outcomes of cardiac (dys) function in women with breast cancer undergoing anthracycline or trastuzumab treatment: study protocol for a systematic review. Systematic Reviews, 8(1), 239.

4.      Craveiro, Nuno; Lopes, Bruno; Tomás, Lara; Fraga, Sofia; Palma, Helena; Afreixo, Vera; Costa-Matos, Luis; Tondela-Viseu Hospital Centre, Internal MedicineL-TRUST: Long-term risk of cancer in patients under statins therapy. A systematic review and meta-analysis (2019) Pharmacoepidemiology and Drug Safety 28(11) 1431-1439 DOI: 10.1002/pds.4895

5.      Cláudia Mello Ribeiro, PhD; Isabela Ribeiro Soares; Rodrigo Guerrero Mendes; Paula Andrea de Santis Bastos; Satie Katagiri; Renato Bacarin Zavilenski; Hudson Felipe Porto de Abreu; Vera Afreixo (2019) “Meta-analysis of the prevalence and risk factors associated with bovine neosporosisTropical Animal Health and ProductionSeptember, 51(7), 1783–1800.

https://doi.org/10.1007/s11250-019-01929-8

6.      Carlos A. C. Bastos, Vera Afreixo, João M.O.S. Rodrigues, Armando J. Pinho, Raquel M. Silva (2019) “Distribution of distances between symmetric words in the human genome: Analysis of regular peaks” Interdisciplinary Sciences: Computational Life Sciences 11, 367-372.

https://doi.org/10.1007/s12539-019-00326-x

7.      Luís Cabral, Vera Afreixo, Rita Meireles, Miguel Vaz, João Frade, Catarina Chaves, Marisa Caetano, Luís Almeida, José Artur Paiva (2019) “Evaluation of procalcitonin accuracy for the distinction between Gram-negative and Gram-positive bacterial sepsis in burn patients”. Journal of Burn Care & Research 40(1), 112-119.

https://doi.org/10.1093/jbcr/iry058

8.      Ana Oliveira, Vera Afreixo, Alda Marques (2018) “Enhancing our understanding of the time course of acute exacerbations of COPD managed on an outpatient basis” International Journal of Chronic Obstructive Pulmonary Disease 13 3759–3766 

https://doi.org/10.2147/COPD.S175890

9.      Cátia Leitão, Paulo Antunes, Vera Afreixo, Paulo André, J. Lemos Pinto, Raquel Fernandes, Marco Costa, J. Mesquita Bastos (2018) “Clinical evaluation of an optical fiber-based probe for the assessment of central arterial pulse waves”. Journal of the Hypertension Research 41, 904-912   https://doi.org/10.1038/s41440-018-0089-2

10.  José Martins, Vera Afreixo, Luís Santos, Marco Costa, José Santos, Lino Gonçalves (2018) “Medical treatment or revascularization as the best approach for spontaneous coronary artery dissection: a meta-analysis”. European Heart Journal: Acute Cardiovascular Care. 7(7), 614-623 https://doi.org/10.1177/2048872617706502

11.  José Martins, Vera Afreixo, Luís Santos, Marco Costa, José Santos, Lino Gonçalves (2018) “Fractional flow reserve-guided strategy in acute coronary syndrome. Is deferring revascularization in acute coronary syndrome patients as safe as in non-acute coronary syndrome patients? A systematic review and meta-analysis”. Arquivos Brasileiros de Cardiologia. 11(4) 542-550 http://dx.doi.org/10.5935/abc.20180170

12.  Luís Cabral, Vera Afreixo, Rita Meireles, Miguel Vaz, Catarina Chaves, Marisa Caetano, Luís Almeida, José Artur Paiva (2018) “Procalcitonin kinetics after burn injury and burn surgery in septic and non-septic patients – a retrospective observational study.” BMC Anesthesiology 18(122) https://doi.org/10.1186/s12871-018-0585-6

13.  Martins, J. L., Adrega, T., Santos, L., Afreixo, V., Viana, J., & Santos, J. (2018). Are football matches dangerous for patients with heart disease? [HeartAtaque trial] – A pilot prospective trial, Jogos de futebol impróprios para cardíacos (HeartAtaque trial) – Estudo piloto prospetivo. Revista Portuguesa de Cardiologia. 37(8) 645-653 https://doi.org/10.1016/j.repc.2017.09.024

14.  Claudia Ribeiro, Lenita Stefani, Simone Lucheis, Juliano Cezar Cruz, Thais Casagrande, Guilherme Souza, Werner Okano, Paula Andrea Bastos, Rafael Pinheiro, Mauro Arruda, Vera Afreixo (2018). “Methicillin-resistant Staphylococcus aureus in poultry and poultry meat: A meta-analysis” Journal of Food Protection 81(7), 1055-1062.

https://doi.org/10.4315/0362-028X.JFP-17-445

15.  Catarina S. Oliveira, Leonor Rocha, Sónia Almeida, Marta Mesquita, Andreia Teixeira Martins, Vera Afreixo, Raquel Zenha, Joana Amorim, Maria Manuel Flores (2018). “Bronquiolite aguda, o que mudou depois da norma de orientação clínica?” Ecos do Minho 13(13), 5-14. ISNN 1646-4745.

16.  Luis Cabral, Vera Afreixo, Filipe Santos, Luís Almeida, José Artur Paiva (2018). “Response to Letter to the Editor: “Comments on procalcitonin for the early diagnosis of sepsis in burn patients: A retrospective study”. Burns 44(4), 1017-1018. http://dx.doi.org/10.1016/j.burns.2017.12.006

17.  Ana Helena Tavares, Jakob Raymaekers, Peter J. Rousseeuw, Raquel M. Silva, Carlos A. C. Bastos, Armando Pinho, Paula Brito, Vera Afreixo (2018). “Comparing reversed complement genomic words based on their distance distributions and frequencies”. Interdisciplinary Sciences: Computational Life Sciences journal 10(1), 1-11. https://doi.org/10.1007/s12539-017-0273-0

18.  Luís Cabral, Vera Afreixo, Miguel Vaz, Catarina Chaves, Marisa Caetano, Luís Almeida, José Artur Paiva (2018). “Checking procalcitonin suitability for prognosis and antimicrobial therapy monitoring in burn patients”. Burns & Trauma 6(1), 10. https://doi.org/10.1186/s41038-018-0112-5

19.  Raquel Diaz, Vera Afreixo, Elmano Ramalheira, Carmen Rodrigues, Bruno Gago (2018). “Evaluation of vancomycin MIC Creep in Methicillin resistant Staphylococcus aureus infections – a systematic review and meta-analysis”. Clinical Microbiology and Infection 24 (2) , 97-104 https://doi.org/10.1016/j.cmi.2017.06.017

20.  Raquel Diaz, Elmano Ramalheira, Vera Afreixo, Bruno Gago (2018). “Rapid screening of methicillin-resistant Staphylococcus aureus carrying the mecC gene in a Portuguese hospital”. Annals of Pathology and Laboratory Medicine (APALM) 5(1) A66-69. ISSN 2349-6983 DOI: 10.21276/APALM.1666 

21.  Sara Escudeiro, Adelaide Freitas & Vera Afreixo (2017) Approximate confidence intervals for a linear combination of binomial proportions: A new variant. Communications in Statistics - Simulation and Computation, 46:9, 7501-7524. http://dx.doi.org/10.1080/03610918.2016.1241408

22.  Cabral L, Afreixo V, Santos F, Almeida L, Paiva JA (2017). “Can procalcitonin be used for the early diagnosis of sepsis in burn patients? A retrospective study”. Burns, 43 (7) 1427-1434 http://dx.doi.org/10.1016/j.burns.2017.03.026

23.  Raquel Diaz, Elmano Ramalheira, Vera Afreixo, Bruno Gago (2017). “Evaluation of vancomycin MIC Creep in Staphylococcus aureus infections”. Journal of Global Antimicrobial Resistance 10 281–284 https://doi.org/10.1016/j.jgar.2017.04.007

24.  Ana Oliveira, Ipek Sem, Yasemin P. Kahya, Vera Afreixo, Alda Marques (2017). “Computerised respiratory sounds can differentiate smokers and non- smokers”. Journal of Clinical Monitoring and Computing. 31(3), 571-580. DOI 10.1007/s10877-016-9887-8

25.  Ana H. M. P. Tavares, Armando J. Pinho, Raquel M. Silva, João M. O. S. Rodrigues, Carlos A. C. Bastos, Paulo J. S. G. Ferreira, Vera Afreixo. “DNA word analysis based on the distribution of the distances between symmetric words”. Scientific Report 2017, 7 (728)  doi:10.1038/s41598-017-00646-2

26.  Vera Afreixo, João M. O. S. Rodrigues, Carlos A. C. Bastos, Ana H. M. P. Tavares, Raquel M. Silva, “Exceptional symmetry by genomic word: A Statistical Analysis”. Interdisciplinary Sciences, Computational Life Sciences. 2017 Mar, 9(1):14-23 DOI: 10.1007/s12539-016-0200-9.

27.  Ana Oliveira, Ângela Monteiro, Cristina Jácome, Vera Afreixo, Alda Marques. “Effects of group sports on health-related physical fitness of overweight youth: A systematic review and meta-analysis”. Scandinavian Journal of Medicine and Science in Sports. 2017 Jun 27(6): 604-611. https://doi.org/10.1111/sms.12784.

28.  Cabral, L., Afreixo, V., Almeida, L., & Paiva, J. A.. “The Use of Procalcitonin (PCT) for Diagnosis of Sepsis in Burn Patients: A Meta-Analysis.” PloS one, 2016 11(12), e0168475.

29.  José Carlos Lopes, Sandra Vilarinho, Vera Afreixo, Luís Almeida, Francisco Luís Pimentel. Mindfulness-Based Intervention in Cancer Recovery: A Pilot Feasibility Study in a Portuguese Sample. International Jornal of Clinical Neuroscienes and Mental Health 2016; 3:4. DOI: http://dx.doi.org/10.21035/ijcnmh.2016.3.4

30.  Paulo, A., Costa, J. D., Pipa, A., Andrade, C., Afreixo, V. “Pain, anxiety and patient satisfaction in office hysteroscopy, is there a link? Are patient satisfaction questionnaires reliable?”. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2016 Mar, 5(3):642-650. http://www.ijrcog.org/index.php/ijrcog/article/view/715.

31.  Vera Afreixo, João M. O. S. Rodrigues and Carlos A. C. Bastos. “The exceptional genomic word symmetry along DNA sequences” BMC Bioinformatics 2016 17(1) 59

DOI 10.1186/s12859-016-0905-0  issn: 1471-2105

32.  Raquel Diaz, Vera Afreixo, Helmano Ramalheira and Bruno Gago. “Methicillin resistant Staphylococcus aureus carrying the new mecC gene – a meta-analysis”. Diagnostic Microbiology and Infectious Disease. 2016 Feb, 84: 135–140.

DOI: http://dx.doi.org/10.1016/j.diagmicrobio.2015.10.014

33.  Antonio A. Paulo, José Damasceno-Costa, Antonio Pipa, Vera M. Afreixo “Hysteroscopy and pain: what risk factors should we consider in office hysteroscopy? Are there really any?” International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2016 Jan, 5(1):74-79. DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20151604

34.  António Paulo, M.H. Solheiro, C. Paulo and Vera Afreixo. “What proportion of women refer moderate to severe pain during Office Hysteroscopy with a mini-hysteroscope? A systematic review and meta-analysis.” Archives of Gynecology and Obstetrics. 2016 Jan; 293(1):37-46 DOI 10.1007/s00404-015-3836-5.

35.  Antonio Paulo, João Mairos, Patrícia Di Martino, Maria Helena Solheiro, Vera Afreixo. Office Hysteroscopy and pain control, a multicenter comparison by scope size and introducing a novel “hysteroscopic anesthesia” technique. Clinical Obstetrics, Gynecology and Reproductive Medicine Journal 2015 1(4): 99-103. doi: 10.15761/COGRM.1000125

36.  Anabela G. Silva, Filipa M.B. Lã, Vera Afreixo. “Pain prevalence in instrumentalist musicians: a systematic review”. Journal Medical Problems of Performing Artists 2015 Mar; 30(1): 8-19.

37.  Vera Afreixo, João M.O.S. Rodrigues and Carlos A. C. Bastos. “Analysis of single-strand exceptional word symmetry in the human genome: new measures”. Biostatistics 2015 Apr; 16(2): 209-21, DOI: 10.1093/biostatistics/kxu041.

38.  Ferreira-Fernandes, Sara L.C. Esteves, Luís Korrodi-Gregório, Georg Luers, Vera Afreixo, Margarida Fardilha, Odete A.B. da Cruz e Silva. “Synphilin-1A is a phosphoprotein phosphatase 1-interacting protein and affects PPP1 sorting to subcellular compartments”.  Journal of Molecular Neuroscience 2015, Volume 55, Issue 2, pp 385-395. DOI: 10.1007/s12031-014-0343-2

39.  Varum, Celeste, Santos, Eduarda and Afreixo, Vera “Recent trends and new evidence in economic literacy among adults”. Journal of Economics and Economic Education Research. Vol. 15, no. 2, pp. 187-206. 2014. Print ISSN: 1533-3604

40.  Vera Afreixo, João M. O. S. Rodrigues and Carlos A. C. Bastos. “Exceptional single strand DNA word symmetry: analysis of evolutionary potentialities”. Journal of Integrative Bioinformatics. vol. 11, no. 3, pp. 1-12. 2014. DOI: 10.2390/biecoll-jib-2014-250

41.  Adelaide Freitas, Vera Afreixo, Sara Escudeiro Cruz. “Mixture models of geometric
distributions in genomic analysis of inter-nucleotide distances”. Statistics, Optimization & Information Computing. vol. 1, pp 8–28, 2013. (oct)

42.  Carlos A. C. Bastos, Vera Afreixo, Sara P. Garcia and Armando J. Pinho. “Inter-STOP symbol distances for the identification coding of regions”. Journal of Integrative Bioinformatics. vol. 10, no. 3, p 1-9, 2013. doi:10.2390/biecoll-jib-2013-230 (nov)

43.  Vera Afreixo, Sara P. Garcia, João M. O. S. Rodrigues. “The breakdown of symmetry in word pairs in 1,092 human genomes”. Jurnal Teknologi. vol. 63, no. 3, p. 1-8, 2013. DOI: 10.11113/jt.v63.1946 (apr)

http://www.jurnalteknologi.utm.my/index.php/jurnalteknologi/article/view/1946

44.  Sara P. Garcia, João M.O.S. Rodrigues, Sérgio Santos, Diogo Pratas, Vera Afreixo, Carlos A.C. Bastos, Paulo J.S.G. Ferreira, and Armando J. Pinho. “A genomic distance for assembly comparison based on compressed maximal exact matches”. IEEE/ACM Transactions on Computational Biology and Bioinformatics. vol. 10, no. 3, pp. 793-798, 2013. doi:  10.1109/TCBB.2013.77 (nov)

45.  Vera Afreixo, Carlos Bastos, Sara Garcia, João Rodrigues, Armando Pinho and Paulo Ferreira. “The breakdown of the word symmetry in the human genome”. Journal of theoretical Biology. vol. 335, p. 153-159. 2013. (oct)

46.  Carlos A. C. Bastos, Vera Afreixo, Armando J. Pinho, Sara P. Garcia, João M. O. S. Rodrigues, Paulo J. S. G. Ferreira, “Inter-dinucleotide distances in the human genome: an analysis of the whole-genome and protein-coding distributions”. Journal of Integrative Bioinformatics. vol. 8, no. 3, pp. 172. 2011.

http://journal.imbio.de/articles/pdf/jib-172.pdf

47.  Vera Afreixo, Carlos A. C. Bastos, Armando J. Pinho, Sara P. Garcia and Paulo J. S. G. Ferreira. Genome analysis with distance to the nearest dissimilar nucleotide”. Journal of Theoretical Biology. vol. 275, no. 1, pp. 52–58. 2011 (doi: 10.1016/j.jtbi.2011.01.038)

http://dx.doi.org/10.1016/j.jtbi.2011.01.038


48.  Freitas, Adelaide; Afreixo, Vera; Pinheiro, Miguel; Oliveira, José Luís; Moura, Gabriela; Santos, Manuel. “Improving the performance of the Iterative Signature Algorithm for the identification of relevant patterns”. Statistical Analysis and Data Mining. vol. 4, no. 1, pp. 71–83. 2011 (doi: 10.1002/sam.10104)

http://onlinelibrary.wiley.com/doi/10.1002/sam.10104/pdf

49.  Vera Afreixo, Carlos A. C. Bastos, Armando J. Pinho, Sara P. Garcia and Paulo J. S. G. Ferreira. “Genome analysis with inter-nucleotide distances”. Bioinformatics. vol. 25, no. 23, pp. 3064–3070, Dec. 2009.

http://bioinformatics.oxfordjournals.org/cgi/reprint/25/23/3064


50.  Armando J. Pinho, António J. R. Neves, Vera Afreixo, Carlos A. C. Bastos and Paulo J. S. G. Ferreira. “A Three-State Model for DNA. Protein-Coding Regions”. IEEE Transactions on Biomedical Engineering, vol. 53, no. 11, pp. 2148-2155, Nov. 2006.

http://www.ieeta.pt/~pjf/PDF/Ferreira2006c.pdf


51.  M. Pinheiro, V. Afreixo, G. Moura, A. Freitas, M. A. Santos, and J. L. Oliveira, “Statistical, computational and visualization methodologies to unveil gene primary structure features”. Methods of Information in Medicine, vol. 45, pp.163-168, issue 2, 2006.

http://www.ncbi.nlm.nih.gov/pubmed/16538282


52.  Gabriela R Moura, Pinheiro M Pinheiro, Raquel M Silva, Isabel M Miranda, Vera M Afreixo, Gaspar Dias, Adelaide Freitas, Jose L Oliveira and Manuel AS Santos. “Comparative context analysis of codon pairs on an ORFeome scale”. Genome Biology vol. 6, issue 3, article R28, Fev. 2005.

http://genomebiology.com/2005/6/3/R28


53.  Vera M. A. Afreixo, Paulo J. S. G. Ferreira and Dorabella M. S. Santos. “Fourier analysis of symbolic data: a brief review”. Digital Signal Processing. vol. 14, no. 6, pp. 523-530, Nov. 2004.

http://www.ieeta.pt/~pjf/PDF/Ferreira2004e.pdf


54.  Vera M. A. Afreixo, Paulo J. S. G. Ferreira and Dorabella M. S. Santos. “The spectrum and symbol distribution of nucleotide”. Physical Review E. vol. 70, no. 3, pp. 031910, Sep. 2004.

http://www.ieeta.pt/~pjf/PDF/Ferreira2004d.pdf


Academic activity

Institution: Mathematics Department – University of Aveiro

Subjects:

  • Medical statistics
  • Epidemiology and Biostatistics
  • Biostatistics
PhD Students:
  • Ana Helena Tavares, “Analysis of inter genomic word distance distributions”
  • Raquel Diaz, “Methicillin resistant Staphylococcus aureus: mecC gene and vancomycin susceptibility”
  • Sara dos Santos Escudeiro,“Confidence intervals for linear combinations of proportions”
  • António Augusto dos Santos Paulo, “Psychosocial and clinical characteristics predicting women’s acceptance of office hysteroscopy”

Masters Students:

  • Mariana Caçoilo, “Caraterização estatística de doentes com MINOCA

  • Sónia Ramos, “Evaluation of a Vancomycin MIC creep at Centro Hospitalar Baixo Vouga”
  • Diogo Miguel Machado Pinto Ribeiro, “Estágio Curricular na Eurotrials”
  • Vera Enes, “Análise das variações genéticas: Caraterização do contexto em que ocorrem variações genéticas”
  • Carmen Rodrigues, “Meta-análise em decisão clínica”
  • Susana Borges, “A estatística que engana!”. Matemática para professores (2º ciclo)
  • Susana Ferreira, “Estudo de sinais epigenéticos no genoma humano”

  • Rui Antunes, “Criação de ferramenta para produção de música genómica usando informação inter-simbólica.”

  • Filipe Alexandre Vasques dos Santos, “Utilidade Clínica da Procalcitonina nos Queimados: Diagnóstico de Infeção, Monotorização de Antibioterapia e Prognóstico”

  • João Antunes, “Distâncias Inter-Simbólicas no ADN”.

  • Maria Fialho, “Estudo de Mercado: A satisfação dos Franchisados em Portugal”.

  • Irina Silva, “As crianças conseguem aprender sobre economia?”.

  • Eduarda Filipa Lopes dos Santos, “Determinantes da Literacia Económica e Financeira”.

  • James Monteiro Aparício, "A simetria das sequências de ADN".

  • Susana Vasconcelos, “Ferramentas para processamento de distâncias inter-simbólicas no ADN”.
  • Sara dos Santos Escudeiro, “Análise estatística de dados de biologia molecular”

  • Elisabete dos Santos Ferreira, “Métodos de biplot aplicados a dados de Biologia Molecular”


Former PhD Students:                                

  • Gisela Ferreira
  • Vera Enes